A Study of Pro-Bnp Compared to Procalcitonin in Patient With Severe Sepsis As a Marker of Diagnosis of Sepsis in Critically Ill Patients

Introduction Early diagnosis of sepsis is the key for improving the survival, therefore biomarkers have an important place in this process because they can indicate the presence or absence of sepsis [1]. Procalcitonin aids in diagnosis and risk stratification of bacterial sepsis [2].Using pro-BNP as inflammatory marker in diagnosing severe sepsis and septic shock is based on cytokines production independent of myocardial dysfunction. Bacterial endotoxins secreted from Gram-negative organisms and Staphylococcus aureus alpha toxin increase the BNP messenger RNA expression. Also the activity of Neutral endopeptidase 24.11 the enzyme responsible for degradation of proBNP decreases in septic shock. Finally, proBNP clearance decreases due to renal dysfunction [3].